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KMID : 1161420220250121126
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Journal of Medicinal Food
2022 Volume.25 No. 12 p.1126 ~ p.1132
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Antifatigue and Anti-Inflammatory Effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge Complex Extracts in Physically Fatigued Mice
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Huang Wen Yan
Pan Jeong-Hoon
Jeong In-Hye
Oh Seong-Ju
Hyun Yong-Geon
Kim Moon-Seong
Han Bok-Kyung
Hong Ji-Youn
Koo Yong-Tae
Lee Ki-Won
Jin Bo-Ra
Noh Dong-Jin
Kim Sang-Ho
Kim Jae-Kyeom
Shin Eui-Cheol
Kim Young-Jun
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Abstract
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Fatigue is a common complaint among people under stress, causing an array of negative effects on physical function. In this study, we investigated the antifatigue and anti-inflammatory effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge complex extracts (CAA) using a treadmill stress test in animal models. The mice were administered various doses of CAA (50-200 mg/kg bw per day) once daily for 21 days. After exhaustive treadmill exercise, the running time of CAA-treated mice increased 1.5 times; fatigue-related biochemical parameters, including lactate dehydrogenase (∼30%), creatine kinase (∼20%), and proinflammatory cytokines interleukin (IL)-1β (∼10%), and IL-6 (∼10%) in the serum and muscle tissue were downregulated compared with those in exercised control mice. This study provides strong evidence for the prevention of CAA-induced inflammatory incidences mediated by the blockade of nuclear factor-κB activation. Collectively, our results indicate that CAA can alleviate symptoms of fatigue in mice as an effective anti-inflammatory agent.
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KEYWORD
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Angelica gigas Nakai, Astragalus membranaceus, Bunge, Cervus elaphus L, anti-inflammatory, antifatigue.
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